ScienceDaily: Latest Science News

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• Antidepressants linked to thicker arteries
• Genetic variation linked to longer telomeres and lower risk of bladder cancer
• PegIFN-lambda shows superior virological response and improved safety than PegIFN-alpha-2a
• Quadruple therapy shows 100 percent SVR for HCV patients previously unresponsive to treatment
• Entry inhibitors show promise as drugs with new MOA for treatment of HBV and HDV infection
• Data suggest liver experts should take care when prescribing novel antiviral HCV drugs
• Thalidomide shows efficacy as adjuvant therapy for hepatocellular carcinoma patients, study suggests
• New data show non-alcoholic fatty liver disease will reach epidemic status in the US
• DNA of 50 breast cancer patients decoded
• Chronic stress of cancer causes accelerated telomere shortening
• Target for lung cancer chemoprevention identified
• Combining MEK and PI3K inhibitors appears encouraging in a safety study with early signs of anti-tumor activity
• BATTLE researchers identify new biomarkers for EGFR inhibition
• New inhibitor prevented lesions, reduced tumor size in basal cell cancer
• Writing assignments boost critical thinking skills for landscape design students
• 'Good cholesterol' nanoparticles seek and destroy cancer cells
• Research on satellite imagery aims to advance sustainable agriculture
• ‘SKIP’-ing splicing forces tumor cells to undergo programmed cell death
• Next-generation computers: Advance in microchannel manufacturing opens new industry applications
• CDC issues updated bloodstream infection prevention guidelines
• When washing becomes a compulsion
• Sleeping through danger: the dormouse approach to survival
• New experimental diagnostic test able to quickly distinguish infection from tuberculosis disease
• First vaccine for viral hepatitis C could become a reality
• Breast health global initiative offers unprecedented tools for developing nations

Antidepressants linked to thicker arteries Posted: 02 Apr 2011 01:38 PM PDT Antidepressant use has been linked to thicker arteries, possibly contributing to the risk of heart disease and stroke, in a study of twin veterans.

Genetic variation linked to longer telomeres and lower risk of bladder cancer Posted: 02 Apr 2011 01:38 PM PDT A common genetic variation links to both bladder cancer risk and to the length of protective caps found on the ends of chromosomes, scientists have reported.

PegIFN-lambda shows superior virological response and improved safety than PegIFN-alpha-2a Posted: 02 Apr 2011 01:38 PM PDT New data found Pegylated Interferon-lambda (PegIFN-lambda) shows superior virological response in HCV patients of genotypes 1-4, with improved safety and tolerability, compared to Pegylated Interferon-alpha (PegIFN-alpha-2a), the current standard of care in chronic HCV.

Quadruple therapy shows 100 percent SVR for HCV patients previously unresponsive to treatment Posted: 02 Apr 2011 01:38 PM PDT New data show that quadruple therapy in chronic hepatitis C (HCV) patients suppressed the emergence of resistant variants and resulted in a 100 percent rate of sustained virological response -- undetectable HCV RNA -- 12 weeks after treatment (SVR12).

Entry inhibitors show promise as drugs with new MOA for treatment of HBV and HDV infection Posted: 02 Apr 2011 01:38 PM PDT Promising new viral hepatitis data show that entry inhibitors a new mechanism of action for drugs to treat viral hepatitis could provide the first new hepatitis B and hepatitis D treatments for many years.

Data suggest liver experts should take care when prescribing novel antiviral HCV drugs Posted: 02 Apr 2011 01:38 PM PDT New novel antiviral compounds for the treatment of hepatitis C virus must be prescribed and monitored by experts and specialists to ensure resistance is minimized, experts say.

Thalidomide shows efficacy as adjuvant therapy for hepatocellular carcinoma patients, study suggests Posted: 02 Apr 2011 01:38 PM PDT Thalidomide has shown potential to be used as the first adjuvant therapy for hepatocellular carcinoma, according to new data.

New data show non-alcoholic fatty liver disease will reach epidemic status in the US Posted: 02 Apr 2011 01:34 PM PDT According to new data the United States could soon be faced with an epidemic of non-alcoholic fatty liver disease, one of the major contributing factors of chronic liver disease, considered as one of the major causes of morbidity and mortality worldwide.

DNA of 50 breast cancer patients decoded Posted: 02 Apr 2011 01:34 PM PDT In the single largest cancer genomics investigation reported to date, scientists have sequenced the whole genomes of tumors from 50 breast cancer patients and compared them to the matched DNA of the same patients' healthy cells. They uncovered incredible complexity in the cancer genomes, but also got a glimpse of new routes toward personalized medicine.

Chronic stress of cancer causes accelerated telomere shortening Posted: 02 Apr 2011 01:34 PM PDT A new study lend credence to the idea that improving quality of life affects stress-related biological markers and possibly the health of people with cancer.

Target for lung cancer chemoprevention identified Posted: 02 Apr 2011 01:34 PM PDT Scientists have identified a biomarker for measuring the success of lung cancer chemoprevention, an emerging frontier in the fight against this disease that has long been stymied by a lack of measureable outcomes.

Combining MEK and PI3K inhibitors appears encouraging in a safety study with early signs of anti-tumor activity Posted: 02 Apr 2011 01:34 PM PDT The combination of two compounds that inhibit two of the most frequently mutated cancer pathways is showing promise in an ongoing Phase I trial, according to new data.

BATTLE researchers identify new biomarkers for EGFR inhibition Posted: 02 Apr 2011 01:33 PM PDT Scientists are continuing their work on the Biomarker-integrated Approaches of Targeted Therapy for Lung Cancer Elimination trial -- known more commonly as the BATTLE trial.

New inhibitor prevented lesions, reduced tumor size in basal cell cancer Posted: 02 Apr 2011 01:33 PM PDT A new hedgehog pathway inhibitor demonstrated efficacy in preventing and treating basal cell cancer among patients with basal cell nevus syndrome, a rare inheritable disease, according to Phase II data.

Writing assignments boost critical thinking skills for landscape design students Posted: 01 Apr 2011 01:15 PM PDT Higher-order thinking skills and the ability to integrate technical knowledge with practical applications are vital for employees, especially in today's challenging job market. Can reflective writing help undergraduate students develop these important skills? A new study offers evidence that the teaching method can be an effective technique to enhance students' critical thinking skills in technical courses.

'Good cholesterol' nanoparticles seek and destroy cancer cells Posted: 01 Apr 2011 01:14 PM PDT High-density lipoprotein's hauls excess cholesterol to the liver for disposal, but new research suggests "good cholesterol" can also act as a special delivery vehicle of destruction for cancer.

Research on satellite imagery aims to advance sustainable agriculture Posted: 01 Apr 2011 01:14 PM PDT Scientists evaluated the potential of multispectral reflectance and seven vegetation indices in the visible and near-infrared spectral range for discriminating and classifying bare soil and several horticultural irrigated crops.

‘SKIP’-ing splicing forces tumor cells to undergo programmed cell death Posted: 01 Apr 2011 11:28 AM PDT When cells find themselves in a tight spot, the cell cycle regulator p21 halts the cell cycle, buying cells time to repair the damage, or if all else fails, to initiate programmed cell death. In contrast to other stress-induced genes, which dispense with the regular transcriptional entourage, p21Cip1 still requires SKIP, a transcription elongation factor that also helps with the editing of transcripts, to be expressed, found researchers.

Next-generation computers: Advance in microchannel manufacturing opens new industry applications Posted: 01 Apr 2011 09:14 AM PDT Engineers have invented a new way to use surface-mount adhesives in the production of low-temperature, microchannel heat exchangers - an advance that will make this promising technology much less expensive for many commercial applications - including next-generation computers, lasers, consumer electronics, automobile cooling systems, fuel processors, miniature heat pumps and more.

CDC issues updated bloodstream infection prevention guidelines Posted: 01 Apr 2011 09:14 AM PDT New guidelines outline steps to eliminate bloodstream infections in patients with intravenous catheters, which are among the most deadly and costly healthcare-associated infections (HAIs).

When washing becomes a compulsion Posted: 01 Apr 2011 09:13 AM PDT Obsessive-compulsive disorder is often diagnosed too late in children and adolescents. Experts point out that appropriate early recognition and treatment can positively affect the course of the disease.

Sleeping through danger: the dormouse approach to survival Posted: 01 Apr 2011 09:13 AM PDT Amid the general rejoicing over the first signs of spring, spare a thought for the humble dormouse, which is about to embark on the most dangerous period of its life. This is the surprising finding of a long-term study of dormouse survival rates in five different countries in Europe.

New experimental diagnostic test able to quickly distinguish infection from tuberculosis disease Posted: 01 Apr 2011 09:13 AM PDT A potential new experimental diagnostic test able to quickly distinguish individuals with active tuberculosis (TB) from those with latent TB infection has been developed. The new diagnostic system could allow more effective strategies to control the spread of the re-emerging pathology.

First vaccine for viral hepatitis C could become a reality Posted: 01 Apr 2011 09:13 AM PDT Early data from phase I trials of an HCV vaccine presented today at the International Liver Congress show encouraging results, with high immunogenicity and good safety profile.

Breast health global initiative offers unprecedented tools for developing nations Posted: 01 Apr 2011 06:12 AM PDT A landmark breast health care publication reveals a multitude of barriers that keep women of developing nations from being screened and treated for breast cancer -- but offers tools to help countries improve their breast care programs.

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